Robert W. Keane, Ph.D.

Professor, Departments of Physiology & Biophysics and Neurological Surgery

The Miami Project to Cure Paralysis
1095 NW 14th Terrace (R-48)
Miami, FL 33136

Research Interests

Areas Of Research



Regulation of Innate Immunity after CNS Trauma

Innate immunity is the first line of defense against pathogens and host-derived signals of cellular stress.  The innate immune response engages an array of receptors to detect stress signals and pathogens and activates cells of the adaptive immune response.  My research focuses on investigating mechanisms that direct normal innate immunity and its dysregulation in central nervous system injury and disease.  Agonists and activation mechanisms of inflammasomes are investigated.  Regulatory mechanisms that potentiate or limit inflammasome activation after injury have been identified, as well as emerging links between innate immunity and Alzheimer’s disease.


Society for Neuroscience
South Florida Veterans Affairs Foundation
National Neurotrauma Society



Modulating Inflammasome Activity and Inflammation in Central Nervous System Injury. Robert W. Keane, Ph.D., W. Dalton Dietrich, Ph.D., Juan Pablo de Rivero Vaccari, Ph.D., Helen M. Bramlett, Ph.D. US Patent Application No. 12/182,886