Robert W. Keane, Ph.D.

Professor, Departments of Molecular Physiology and Biophysics, Neurological Surgery and Microbiology and Immunology

The Miami Project to Cure Paralysis
1095 NW 14th Terrace (R-48)
Miami, FL 33136

Research Interests

Areas Of Research



Regulation of Innate Immunity after CNS Trauma

Innate immunity is the first line of defense against pathogens and host-derived signals of cellular stress and in sterile inflammation.  The innate immune response engages an array of receptors to detect stress signals and pathogens and activates cells of the adaptive immune response.

My research focuses on investigating mechanisms that regulate inflammasomes in the normal innate immune response and the dysregulation in central nervous system injury and inflammatory diseases.

Drug discovery for agonists and activation mechanisms of inflammasomes are being developed.  Regulatory mechanisms that potentiate or limit inflammasome activation after injury have been identified and patented, as well as emerging links between innate immunity and Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis and Cancer.

Our laboratory is also engaged in a robust biomarker program to identify new reliable biomarkers for a variety of inflammatory diseases.

Canonical and Noncanonical Inflammasome Pathways
Canonical and Noncanonical Inflammasome Pathways



Society for Neuroscience
South Florida Veterans Affairs Foundation
National Neurotrauma Society

Visit the website for Dr. Keane’s Startup Company, Inflamacore, LLC.

Dr. Keane also serves on the Scientific Advisory Board for ZyVersa Therapeutics, Inc.


Modulating Inflammasome Activity and Inflammation in Central Nervous System Injury. Robert W. Keane, Ph.D., W. Dalton Dietrich, Ph.D., Juan Pablo de Rivero Vaccari, Ph.D., Helen M. Bramlett, Ph.D. US Patent Application No. 12/182,886