Suhrud M. Rajguru, Ph.D.

Co-Director, Institute for Neural Engineering

Associate Professor, Biomedical Engineering & Otolaryngology
Assistant Director, University of Miami CTSI Team Science

Suhrud Rajguru, Ph.D.

The Miami Project to Cure Paralysis
1095 NW 14th Terrace (R-48)
Miami, FL 33136

Biography

Research Interests

Areas Of Research

Publications

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Suhrud Rajguru, Ph.D., is an Associate Professor of Biomedical Engineering and Otolaryngology at the University of Miami and a co-founder and Chief Scientific Officer of Restor-Ear Devices, LLC. He completed his undergraduate studies in Mumbai, India prior to pursuing doctoral studies at the University of Utah. Dr. Rajguru’s research foci are on the investigations of pathophysiology, the diagnosis and treatment of various hearing and balance disorders. He has authored numerous peer-reviewed publications and is a named inventor on several issued and pending patent applications. His research is supported by the National Institutes of Health and industry partners and he is actively involved in the education and mentoring of undergraduate and graduate students. At the University of Miami, he is the Co-Director of the Institute for Neural Engineering and Assistant Director of the Team Science program at the Miami Clinical and Translational Science Institute.

Therapeutic Hypothermia

My laboratory and collaborators (W. Dalton Dietrich and Michael Hoffer) at the University of Miami have been at the forefront of using therapeutic hypothermia applied locally to the inner ear to benefit patients undergoing cochlear implantation. Now we have expanded its application using a custom-designed device and a unique non-invasive approach to noise-induced hearing loss. Our work on therapeutic hypothermia has been published in multiple peer-reviewed studies and presented at national and international conferences.

The application proposes to carry out experiments that will test a novel combination therapy for enhanced protection of cochlear structures and residual hearing function. We have formed partnerships with neurotologists, audiologists, biomedical engineers and translational scientists with interdisciplinary expertise to address this major challenge in the field of cochlear implant research.

We have built partnerships with medical device and cochlear implant manufacturers, Lucent Medical Systems and Cochlear, which will provide critical regulatory and engineering support necessary to move this technology into operating rooms.

This work is funded by NIH and industry support to Dr. Rajguru: R01DC008846 and R01DC008846 (Holstein, PI).


Vestibular disorders: Benign Paroxysmal Positional Vertigo

With Dr. Richard Rabbitt at the University of Utah, we have developed biomechanical and experimental models to understand, diagnose and treat one of the most common vestibular disorders: BPPV or Benign Paroxysmal Positional Vertigo. We addressed in detail its pathology and examined the role of otoconia in the vestibular system in evoking the pathological symptoms. This work significantly enhanced our understanding of the disorder.

 

4th Annual Neural Engineering Symposium (November 2020)

Cooling the Nervous System (November 2018)

Therapeutic Hypothermia relevant references

Jiang W, Rajguru SM, (2018) Eye Movements Evoked by Pulsed Infrared Radiation of the Rat Vestibular System. Ann Biomed Eng. 2018 May 29. doi: 10.1007/s10439-018-2059-x. [PMID: 29845411]. PMCID: PMC6095805

Barrett JN, Rincon S, Singh J, Matthewman C, Pasos J, Barrett EF, Rajguru SM. (2018) Pulsed Infrared Releases Ca2+ from the Endoplasmic Reticulum of Cultured Spiral Ganglion Neurons. J Neurophysiol. 2018 Apr 18. doi: 10.1152/jn.00740.2017. [PMID: 29668377]. PMCID: PMC6139448.

Vestibular disorders: Benign Paroxysmal Positional Vertigo relevant references

Rajguru SM and Rabbitt RD (2007) Afferent Responses During Experimentally Induced Semicircular Canalithiasis, J Neurophysiol. 97(3): 2355-63. [PMCID: PMC2621011].

Ifediba MA, Rajguru SM, and Rabbitt RD (2007) The Role of Three-canal Biomechanics in Angular Motion Transduction by the Human Vestibular Labyrinth. Ann Biomed Eng. 35(7): 1247-63. [PMID: 17377842].

Rajguru SM, Ifediba MA and Rabbitt RD (2005) Biomechanics of Horizontal Canal Type Benign Paroxysmal Positional Vertigo. J Vest Res. 15(3): 203-214. [PMCID: PMC2716391].

Rajguru SM, Ifediba MA and Rabbitt RD (2004) Three-dimensional Biomechanical Model of Benign Paroxysmal Positional Vertigo. Ann Biomed Eng. 32(6): 831-846. [PMID: 15255214] PMCID: PMC3005417

 

PROFESSIONAL AFFILIATIONS/MEMBERSHIPS

 

  • Association of the Research in Otolaryngology
  • Society for Neuroscience
  • Barany Society
  • Biomedical Engineering Society