Neuroregeneration research is aimed at promoting the regrowth and repair of nervous system tissues. This includes the generation of new neuronal cells as well as promoting axon regrowth and remyelination of damaged neurons.
Scientists at The Miami Project employ sophisticated methods to study the potential regenerative capabilities of the central nervous system after injury. Their neuroregeneration work includes investigation of the regenerative potential of cell transplantation strategies. (See Cell Transplantation). In addition to a cellular approach, a number of laboratories study the molecular and genetic cues that neurons receive during their development. By understanding the mechanisms that regulate axon regeneration and guidance, researchers hope to develop molecular and genetic treatment approaches to stimulate axon growth.
An exciting area of research at The Miami Project is high content screening of drugs and genes that promote axonal growth and regeneration. Using a unique state-of-the-art screening method, researchers at The Miami Project screen thousands of untested compounds and genes to identify new potential therapies for spinal cord injury. In preclinical studies, investigators are now testing several of the compounds and genes that have shown great potential to stimulate axonal growth in the injured spinal cord.
Barth A. Green, M.D.
James D. Guest, M.D., Ph.D.