The Miami Project to Cure Paralysis is thankful to our friends, volunteers and the spinal cord injury community for supporting our research, educational and outreach programs. Over the past year, we have made significant advances in our translational and clinical programs for spinal cord injury and other neurological disorders.

With our Department of Neurological Surgery colleagues, we have expanded our multidisciplinary programs and established new collaborations using innovative approaches addressing complex issues related to brain and spinal cord injury.

The Miami Project therapeutic pipeline is helping to move new discoveries to the clinic with treatment interventions targeting the acute, subacute and chronic phases of injury. Significant progress is being made in the area of acute care where the cellular and molecular mechanisms underlying neuroprotective interventions such as therapeutic hypothermia are being clarified to enhance our human trials.

More exciting news includes recent NIH funding for a significant drug discovery program to identify and test novel compounds to promote successful axonal regeneration in people living with spinal cord injury. Working with industry, innovative approaches are being developed for enhancing motor function by stimulating cranial and intraspinal circuits, and are also showing great promise in enhancing motor function in people living with chronic paralysis. Also, our human Schwann cell program is now testing the benefits of small extracellular vesicles released from human cells to promote regenerative processes in preclinical as well as clinical studies.

The new Christine E. Lynn Rehabilitation Center is providing outstanding care for people with many types of injuries and disabilities. There, clinical researchers are evaluating rehabilitation approaches including neuromodulation to activate and enhance circuit function responsible for motor and sensory function in people living with disabilities. Our growing scientific community is fortunate to work in two state-of-the-art facilities where new discoveries in the Lois Pope LIFE Center can be seamlessly translated to the Lynn Rehabilitation Center where everyday advances are being made to change medical care.

These are exciting times for The Miami Project as we translate spinal cord injury discoveries to other neurological disorders including stroke, traumatic brain injury and  neurodegenerative diseases. We sincerely appreciate the continued support of our friends and colleagues for our programs focusing on novel strategies to improve the quality of life of all individuals living with paralysis and other neurological disorders.

Barth A. Green, M.D., F.A.C.S. – Co-Founder
W. Dalton Dietrich, Ph.D. – Scientific Director
Allan D. Levi, M.D., Ph.D., F.A.C.S. – Clinical Director