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Pain Study

UTILITY OF MRS BRAIN BIOMARKERS OF PAIN PHENOTYPES AFTER TRAUMATIC BRAIN INJURY (TBI)

Purpose

To compare subjects with TBI and chronic pain (TBICP), subjects with TBI and no chronic pain (TBINoP), and matched pain-free controls (CNoP) on Magnetic Resonance Spectroscopy (MRS) and Diffusion Kurtosis Imaging (DKI) measures.

 

Criteria

Group I-TBI and chronic pain, fluent in English, 18-50 years old, non-penetrating head injury, TBI must have occurred at least 6 months prior to entering study, mild or moderate TBI, moderate chronic pain for minimum of three months.

Group II-Pain-free TBI, fluent in English, 18-50 years old, non-penetrating head injury, TBI must have occurred at least 6 months prior to entering study, mild or moderate TBI.

Group III-Pain-free controls, fluent in English, 18-50 years old.

 

Duration

2 visits, each lasting 3-4 hours over a 2-4 week period.

Enrollment Open Until

Extended recruitment date.  No end date.

Principal Investigator/Contact

Dr. Eva Widerstrom-Noga / Loriann Fleming or Jessica Cambrdige