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Pain Study

UTILITY OF MRS BRAIN BIOMARKERS OF PAIN PHENOTYPES AFTER TRAUMATIC BRAIN INJURY (TBI)

Purpose

To compare subjects with TBI and chronic pain (TBICP), subjects with TBI and no chronic pain (TBINoP), and matched pain-free controls (CNoP) on Magnetic Resonance Spectroscopy (MRS) and Diffusion Kurtosis Imaging (DKI) measures.

 

Criteria

Group I-TBI and chronic pain, fluent in English, 18-50 years old, non-penetrating head injury, TBI must have occurred at least 6 months prior to entering study, mild or moderate TBI, moderate chronic pain for minimum of three months.

Group II-Pain-free TBI, fluent in English, 18-50 years old, non-penetrating head injury, TBI must have occurred at least 6 months prior to entering study, mild or moderate TBI.

Group III-Pain-free controls, fluent in English, 18-50 years old.

 

Duration

2 visits, each lasting 3-4 hours over a 2-4 week period.

Enrollment Open Until

Extended recruitment date.  No end date.

Principal Investigator/Contact

Dr. Eva Widerstrom-Noga / Loriann Fleming or Jessica Cambrdige

ALTERED BODY REPRESENTATION IN PEOPLE WITH SPINAL CORD INJURY AND ITS ASSOCIATION WITH PAIN SENSATION

Purpose

To define changes in body ownership underlying compromised multisensory integration in spinal cord injury (SCI) individuals by using the rubber hand illusion procedure (RHI); ii) to determine the relation between compromised multisensory integration after SCI and its impact on pain.

 

Criteria

Group I: SCI and chronic pain (SCICP) group: Men or women, fluent in English, 18-50 years of age who have: (1) Incomplete, level of injury from (C2-T10); (2) persistent pain for a minimum of three months prior to entering the study that is at least moderate in severity, defined as ≥ 4 on an Numeric Rating Scale (NRS) ranging 0 to 10.
Group II: SCI no pain (SCINP) group: Same entry criteria as the SCICP group less the pain criterion.

Group III: Healthy control subjects group No Pain: Participants will be men or women, fluent in English, 18-50 years of age who are non-injured and otherwise healthy

 

Duration

1 visit lasting 1.5 hour

Enrollment Open Until

August 2020

Principal Investigator/Contact

Dr. Eva Widerstrom-Noga / Dr. Roberta Vastano

DEVELOPMENT OF PAIN EDUCATION FOR IMPROVING PAIN HEALTH LITERACY AND QUALITY OF LIFE AFTER SPINAL CORD INJURY

Purpose

To incorporate the perspectives from individuals with Spinal Cord Injury or SCI who experience neuropathic pain, their significant others, and SCI healthcare providers to develop a relevant, consumer-grounded educational resource regarding SCI-related pain for the SCI community, their families, and healthcare providers.

 

Criteria

Group I: People Who have SCI-related Pain for 6 months or longer

Group II: People who are Close to a person with SCI-related Pain

Group III: Healthcare Providers who serve the SCI patient population (up to 75 years of age)

 

Duration

3 visits lasting 30 minutes to 2 hours

Enrollment Open Until

December 2020

Principal Investigator/Contact

Dr. Eva Widerstrom-Noga / Loriann Fleming