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Current Activity Studies

LOWER BODY BLOOD FLOW DURING AND AFTER ELECTRICALLY STIMULATED CYCLING IN PERSONS WITH SPINAL CORD INJURY

Purpose

To examine the use of electrical stimulation when applied on the skin to initiate muscle contraction and cycling motion in persons with SCI.  The procedures will test the effect electric stimulation cycling on blood flow to various muscles and skin areas of the lower extremities.

 

Criteria

Motor complete or incomplete, C1-L1 traumatic or non-traumatic spinal injury; 18-60 years old; ≥1 year post-injury; responsive to electrical stimulation (as determined by previous knowledge or during an assessment).

 

Duration

Three visits over the course of approximately one week, for a total of about 4 – 5 hours.

 

Enrollment Open Until

20 people complete the study

 

Principal Investigator/Contact

Dr. Mark S. Nash / David McMillan

STAKEHOLDER PERCEPTIONS AND CLINICAL ASSESSMENT OF CARDIOMETABOLIC DISEASE/SYNDROME AFTER SPINAL CORD INJURY

Purpose

It is known that risks for heart and blood vessel disease (atherosclerosis) and abnormal sugar metabolism (diabetes) are elevated after SCI. The investigators don’t know whether individuals were ever told by their physician if have these risks, or currently have these risks. We are interested to determine if individuals with SCI are overweight, have abnormal sugar metabolism (insulin resistance or diabetes), have blood pressure that is too high or have blood fats that are outside of acceptable ranges. This information will be measured and compared with the individuals’ clinical report of their physician’s or other health care professionals (nurses or therapists) advice of having these risks. As these risks may change with time after SCI, the Investigators are also interested in seeing whether this information changes after one and two years of living with a SCI.

 

Criteria

SCI men and women. 18 – 70 years old; Motor complete or incomplete, C5-L1, traumatic spinal injury; within 2 months of discharge from initial rehabilitation post-injury;

 

Duration

Approximately 24 months total, including a screening visit to assess risk for heart, blood vessel disease and blood sugar metabolism for the individual with SCI. Testing periods at time of enrollment, 12 months and 24 months after.

 

Enrollment Open Until

September 2020

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Luisa Betancourt

STATIN MONOTHERAPY FOR TREATMENT OF ENDOCRINE METABOLIC DISEASE RISK

Purpose

Research study to determine the safety and efficacy of statin therapy (which is typically used to lower cholesterol and treat heart disease) for increasing bone mineral density (bone health) among adults with chronic motor-complete Spinal Cord Injury.

 

Criteria

Non-progressive spinal cord injury; SCI men and women. SCI 18 -60 years old; with a chronic Motor complete SCI (C1-T10 AIS A/B); 2), traumatic spinal injury; ≥2 year post-injury; able to provide a contact number, and ability to attend the study visits and be able to take oral medications and swallow independently.

 

Duration

Approximately 12-16 months total, including a screening visit to assess eligibility. Additional testing period visits and phone calls scheduled throughout the course of the study.

 

Enrollment Open Until

September 2019

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Luisa Betancourt

 

FUNCTIONAL SITTING TOLERANCE AFTER SPINAL CORD INJURY: BALANCE AND ORTHOSTATIC HYPOTENSION

Purpose

This study will examine factors that impact your ability to remain in an upright, seated position. First we will test the strength of your diaphragm, the main breathing muscle in your body. Next, we will examine how well your body controls your blood pressure in different positions. Last, we will assess your sitting balance.

 

Criteria

Motor complete or incomplete; traumatic or non-traumatic spinal injury for ≥1 year; 18-65 years old; non-smoker.

Duration

Four visits over the course of approximately 2 weeks, for a total of approximately 12 hours.

 

Enrollment Open Until

40 people complete the study.

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Annie Palermo