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Current Activity Studies

A LIFESTYLE INTERVENTION TARGETING ENHANCED HEALTH AND FUNCTION FOR PERSONS WITH CHRONIC SCI IN CAREGIVER/CARE-RECEIVER RELATIONSHIPS: EFFECTS OF CAREGIVER CO-TREATMENT

Purpose

To determine the effect in health and functional impact of a lifestyle intervention in people with chronic SCI and their caregivers. We are interested in seeing if the complementary caregiver intervention enhances health and functional benefits obtained by the SCI individual.

 

Criteria

SCI men and women and their caregivers (enrollment as a couple). SCI: motor complete or incomplete, C5-L1, traumatic or non-traumatic, non-progressive spinal injury; 18-65 years old; ≥1 year post-injury. Caregivers: healthy; 18-65 years old; who provide social and/or physical support to the SCI participants.

 

Duration

Approximately 14 months total, including a screening visit to assess cardiometabolic risk for the SCI individual. Additional testing periods at time of enrollment, baseline, and 6 and 12 months for SCI and caregivers.

 

Enrollment Open Until

September 2020

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Luisa Betancourt

STAKEHOLDER PERCEPTIONS AND CLINICAL ASSESSMENT OF CARDIOMETABOLIC DISEASE/SYNDROME AFTER SPINAL CORD INJURY

Purpose

It is known that risks for heart and blood vessel disease (atherosclerosis) and abnormal sugar metabolism (diabetes) are elevated after SCI. The investigators don’t know whether individuals were ever told by their physician if have these risks, or currently have these risks. We are interested to determine if individuals with SCI are overweight, have abnormal sugar metabolism (insulin resistance or diabetes), have blood pressure that is too high or have blood fats that are outside of acceptable ranges. This information will be measured and compared with the individuals’ clinical report of their physician’s or other health care professionals (nurses or therapists) advice of having these risks. As these risks may change with time after SCI, the Investigators are also interested in seeing whether this information changes after one and two years of living with a SCI.

 

Criteria

SCI men and women. 18 – 70 years old; Motor complete or incomplete, C5-L1, traumatic spinal injury; within 2 months of discharge from initial rehabilitation post-injury;

 

Duration

Approximately 24 months total, including a screening visit to assess risk for heart, blood vessel disease and blood sugar metabolism for the individual with SCI. Testing periods at time of enrollment, 12 months and 24 months after.

 

Enrollment Open Until

September 2020

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Luisa Betancourt

STATIN MONOTHERAPY FOR TREATMENT OF ENDOCRINE METABOLIC DISEASE RISK

Purpose

Research study to determine the safety and efficacy of statin therapy (which is typically used to lower cholesterol and treat heart disease) for increasing bone mineral density (bone health) among adults with chronic motor-complete Spinal Cord Injury.

 

Criteria

Non-progressive spinal cord injury; SCI men and women. SCI 18 -60 years old; with a chronic Motor complete SCI (C1-T10 AIS A/B); 2), traumatic spinal injury; ≥2 year post-injury; able to provide a contact number, and ability to attend the study visits and be able to take oral medications and swallow independently.

 

Duration

Approximately 12-16 months total, including a screening visit to assess eligibility. Additional testing period visits and phone calls scheduled throughout the course of the study.

 

Enrollment Open Until

September 2019

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Luisa Betancourt

 

POSTPRANDIAL FAT METABOLISM FOLLOWING AN ACUTE EXERCISE BOUT IN PERSONS WITH SPINAL CORD INJURIES

Purpose

To determine the effect of spinal cord injury (SCI) on the metabolism of fats following feeding of a liquid “mixed meal” containing 50% carbohydrates, 35% fat, and 15% protein. Secondarily, to determine the effect of pre-meal exercise on metabolism of fats from the meal.

 

Criteria

Men with and without SCI. SCI: motor complete or incomplete, C5-L1, traumatic or non-traumatic, non-progressive spinal injury; 18-60 years old; ≥1 year post-injury. Neurologically intact: healthy; 18-60 years old.

 

Duration

Approximately 3-4 weeks total, including a screening visit to assess body composition and cardiorespiratory fitness for the SCI individual. Following assessment, two experimental trials will occur separated by approximately 1 week. Each full trial requires ~8.5 hr of testing.

 

Enrollment Open Until

June 2020

 

Principal Investigator/Contact

Dr. Kevin A. Jacobs / Dr. Mark S. Nash