Howard B. Levene, M.D., Ph.D., FAANS, FACS
Assistant Professor, Clinical Neurological Surgery and Clinical Rehabilitation Medicine
Phosphodiesterase Inhibitors after SCI Schwann Cell Transplantation after SCI
After a spinal cord injury, there is a cascade of factors that contribute to secondary injury, including cyclic AMP. Along with Dr. Damien Pearse and our industry partners (Anacor, which has been acquired by Pfizer), we are investigating mechanisms to reduce the effect of cyclic AMP after spinal cord injury using Phosphodiesteras Inhibitors. My portion of this research focuses on coordinating the large animal model for trialling the proposed therapeutic agents.
I have also been involved with Schwann cell transplantation. One proposed therapy for spinal cord injury is to introduce cells to the injury site to help repair, restore, or support existing neurons. My research focused on a large animal model to study the effect and behavior of transplanted autologous Schwann cells. I have been involved in the refinement of this animal model. This approach allows for the scientific study of the behavior of implanted cells and generates the groundwork for clinical trials. Research utilizing this model is done in collaboration with clinicians and scientists at The Miami Project such as Drs. Levi, Guest, Solano, Pearse, Wood, Bunge, and many more.
Howard B. Levene, M.D., Ph.D.
- The Miami Project to Cure Paralysis
1095 NW 14th Terrace (R-48)
Miami, FL 33136
- (305) 243-6946
2010 Veterans Administration Hosptial, Miami
2009 Attending Faculty, University of Miami Hospital
2009 Attending Faculty, Jackson Memorial Hospital
2008 Spine Fellowship University of Miami/Jackson Memorial Hospital
2008 Chief Neurosurgical Resident Temple University Hospital
2007 Neurosurgical Resident Temple University Hospital
2002 Preliminary Surgical Internship Temple University Hospital
2001 MD/Ph.D program University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School
1999 Ph.D. in Biomedical Engineering Rutgers University and the University of Medicine and Dentistry of New Jersey Graduate School of Biomedical Sciences
1993 Bachelor of Science in Engineering University of Pennsylvania, The School of Engineering and Applied Science