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Human Motor Control and Plasticity

Bilateral Control of Arm Movement after Spinal Cord Injury

Purpose

Most spinal cord injuries in humans damage both sides of the spinal cord resulting in asymmetric function in the arms. The goal of our study is to investigate to which extent motion of one arm affects movement of the other arm by using noninvasive brain stimulation, kinematics, Robotic KINARM, and multi-channel electromyographic analysis in individuals with spinal cord injury and uninjured controls.

 

Criteria

Any cause, any severity of cervical SCI; males and females; 18-80 years old; ≥6 months post-injury.

 

Duration

1-2 hour session, 1 to 30 session(s) according to availability

 

Enrollment open until

Open-ended

 

Principal Investigator/Contact

Dr. Monica A. Perez / Dr. Yuming Lei

 

 

Synchronization of Corticospinal Volleys after Spinal Cord Injury

Purpose

In this project we use noninvasive brain stimulation to assess the changes in timing of corticospinal volleys in individual with spinal cord injury and uninjured controls. We use this information to promote motor recovery by means of plasticity protocols.

 

Criteria

Any cause, any severity, C1-T12 SCI; males and females; 18-80 years old; ≥6 months post-injury; right hand dominance for control subjects.

 

Duration

2 hour session, 1 to 30 session(s) according to availability

 

Enrollment open until

Open-ended

 

Principal Investigator/Contact

Dr. Monica A. Perez / Dr. Hang Jin Jo

 

 

Reorganization of Descending Pathways after Spinal Cord Injury

Purpose

To investigate reorganization of cortical, corticospinal, and reticulospinal motor pathways after incomplete spinal cord injury.

 

Criteria

Any cause, motor incomplete, C1-T12 SCI; males and females; 18-80 years old; ≥6 months post-injury.

 

Duration

2 – 5 of 2.5 hour visits

 

Enrollment open until

Open-ended

 

Principal Investigator/Contact

Dr. Monica A. Perez / Dr. Francisco Benavides

 

 

Relationship between Clinical and Physiological Outcomes of Sensorimotor Function and Spasticity

Purpose

To investigate the relationship between clinical and physiological outcomes of sensory and motor function and spasticity after spinal cord injury.

Criteria

Any cause, any severity, C1-T12 SCI; males and females; 18-80 years old; ≥2 weeks post-injury.

Duration

2-5 of 2.5 hour visits.

Enrollment open until

Open-ended

Principal Investigator/Contact

Dr. Monica A. Perez / Dr. Sina Sangari

 

Targeted Neuroplasticity after Spinal Cord Injury

Purpose

To elicit targeted dependent plasticity within the spinal cord and the primary motor cortex by using noninvasive brain and peripheral nerve stimulation to enhance corticospinal transmission and voluntary motor output.

Criteria

Any cause, any severity, C1-T12 SCI; males and females; 18-80 years old; ≥6 months post-injury.

Duration

2-3 hour session, 1 to 30 sessions according to availability

Enrollment open until

Open-ended

Principal Investigator/Contact

Dr. Monica A. Perez / Dr. Hang Jin Ho / Dr. Yuming Lei

 

Hand and Upper-Limb Motor Training

Purpose

We examine the effect of finger and arm muscles training on sensorimotor function and physiological and behavioral outcomes in humans with and without spinal cord injury.

Criteria

Any cause, any severity, C1-T12 SCI; males and females; 18-80 years old; ≥2 weeks post-injury.

Duration

10 to 30 sessions according to availability.

Enrollment open until

Open-ended

Principal Investigator/Contact

Dr. Monica A. Perez / Audrey Wilson

 

Acute Intermittent Hypoxia and Motor Function

Purpose

An increasing number of studies support the view that exposure to brief episodes of hypoxic air (acute intermittent hypoxia, AIH) enhances voluntary motor output in humans with and without motor disorders. The goal of our study is to examine the effect of repeated exposure to AIH on sensorimotor function and physiological and behavioral outcomes in humans with and without spinal cord injury.

Criteria

Any cause, any severity, C1-T12 SCI; males and females; 18-80 years old; ≥2 weeks post-injury.

Duration

1 to 30 sessions according to availability.

Enrollment open until

Open-ended

Principal Investigator/Contact

Dr. Monica A. Perez / Dr. Lasse Christiansen