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Current Activity Studies

LOWER BODY BLOOD FLOW DURING AND AFTER ELECTRICALLY STIMULATED CYCLING IN PERSONS WITH SPINAL CORD INJURY

Purpose

To examine the use of electrical stimulation when applied on the skin to initiate muscle contraction and cycling motion in persons with SCI.  The procedures will test the effect electric stimulation cycling on blood flow to various muscles and skin areas of the lower extremities.

 

Criteria

Motor complete or incomplete, C1-L1 traumatic or non-traumatic spinal injury; 18-60 years old; ≥1 year post-injury; responsive to electrical stimulation (as determined by previous knowledge or during an assessment).

 

Duration

Three visits over the course of approximately one week, for a total of about 4 – 5 hours.

 

Enrollment Open Until

20 people complete the study

 

Principal Investigator/Contact

Dr. Mark S. Nash / David McMillan

EFFECTS OF ACUTE INTERMITTENT HYPOXIA (AIH) ON METABOLISM AND DYSGLYCEMIA, IN OVERWEIGHT/OBESE PERSONS WITH SCI

Purpose

The study will examine the effects of periods of low oxygen breathing (AIH) on the ability of the body to use sugar in your blood and on metabolism at rest and during exercise in individuals with SCI and a non-injured control group (CON).

 

Criteria

Motor complete or incomplete, C5-L1 traumatic or non-traumatic spinal injury or do not have a spinal cord injury (CON); 18-60 years old; ≥1 year post-injury; be overweight or obese as classified by Body Mass Index of ≥ 25.0 (CON) and ≥ 22.0 (SCI).

 

Duration

11-13 visits over the course of approximately 3-6 weeks, for a total of approximately 20-22 hours.

 

Enrollment Open Until

20 people complete the study: 10 with SCI and 10 non-injured controls.

 

Principal Investigator/Contact

Dr. Mark S. Nash / David McMillan

FITNESS AND INDEPENDENCE AFTER SCI: DEFINING MEANINGFUL CHANGE AND THRESHOLDS

Purpose

To determine a) how much the fitness of an individual living with spinal cord injury or disease (SCI/D) must increase to support a meaningful gain in independence and b) the lowest fitness level that allows most people to transfer independently between a) wheelchair and bed, b) wheelchair and toilet or tub, and c) wheelchair and car.

 

Criteria

Any level or severity of injury (traumatic or non-traumatic, if non-progressive); ≥18 years old; ≥6 months post-injury; can bend both elbows against gravity; except for spasms, cannot use their leg muscle to help with transfers; have limited shoulder pain.

 

Duration

Four to five hours total, can be completed in one visit or two to three visits.

 

Enrollment Open Until

September 29, 2017

 

Principal Investigator/Contact

Dr. Rachel Cowan / Chris Fitzmaurice

EFFECTS OF ACUTE BODY WEIGHT SUPPORT TREADMILL TRAINING (BWSTT) AND ACUTE INTERMITTENT HYPOXIA (AIH) ON METABOLISM, DYSGLYCEMIA, AND CARDIOVASCULAR-AUTONOMIC FUNCTIONS IN PERSONS WITH SCI

Purpose

The study will examine the effects of both assisted treadmill walking (BWSTT) and periods of low oxygen breathing (AIH) on control of blood pressure, heart and lung functions, and the ability of the body to use sugar in your blood. The study will test each of these therapies separately, and then together to determine whether they work together to promote even greater effects.

 

Criteria

Motor complete or incomplete, C1-L1 traumatic or non-traumatic spinal injury; 18-60 years old; ≥1 year post-injury; height between 5 feet and 6 feet-3 inches.

 

Duration

12-15 visits over the course of approximately 4 weeks, for a total of approximately 22-25 hours.

Enrollment Open Until

15 people complete the study.

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Jennifer Maher

A LIFESTYLE INTERVENTION TARGETING ENHANCED HEALTH AND FUNCTION FOR PERSONS WITH CHRONIC SCI IN CAREGIVER/CARE-RECEIVER RELATIONSHIPS: EFFECTS OF CAREGIVER CO-TREATMENT

Purpose

To determine the effect in health and functional impact of a lifestyle intervention in people with chronic SCI and their caregivers.  We are interested in seeing if the complementary caregiver intervention enhances health and functional benefits obtained by the SCI individual.

 

Criteria

SCI men and women with their caregivers (enrollment as a couple).  SCI: motor complete or incomplete, C5-L1 traumatic or non-traumatic, non-progressive spinal injury; 18-65 years old; ≥1 year post-injury. Caregiver: healthy; 18-65 years old; who provide social and/or physical support to the SCI participants.

 

Duration

Approximately 14 months total, including a screening visit to assess cardiometabolic risk for the SCI individual.  Additional testing periods at time of enrollment, baseline, and 6 and 12 months for SCI and caregivers.

 

Enrollment Open Until

September 2020.

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Luisa Betancourt

ENERGY EXPENDITURE DURING AND AFTER ELECTRICALLY STIMULATED CYCLING IN PERSONS WITH SPINAL CORD INJURY

Purpose

To examine the use of electrical stimulation when applied on the skin to initiate muscle contraction and cycling motion in persons with SCI.  The procedures will test the number of calories that burn during and following a 30-minute cycling session in which the electrical stimulation contracts the thigh muscles (front and back) and buttocks muscles.  The investigators will compute the number of calories burned by monitoring metabolism during cycling, and will see whether this agrees with software used by the cycle to calculate energy consumption.

 

Criteria

Motor complete or incomplete, C1-L1 traumatic or non-traumatic spinal injury; 18-60 years old; ≥1 year post-injury; responsive to electrical stimulation (as determined by previous knowledge or during an assessment).

 

Duration

Five visits over the course of approximately two weeks, for a total of about 7 – 9 hours.

 

Enrollment Open Until

20 people complete the study.

 

Principal Investigator/Contact

Dr. Mark S. Nash / David McMillan

STAKEHOLDER PERCEPTIONS AND CLINICAL ASSESSMENT OF CARDIOMETABOLIC DISEASE/SYNDROME AFTER SPINAL CORD INJURY

Purpose

It is known that risks for heart and blood vessel disease (atherosclerosis) and abnormal sugar metabolism (diabetes) are elevated after SCI. The investigators don’t know whether individuals were ever told by their physician if have these risks, or currently have these risks. We are interested to determine if individuals with SCI are overweight, have abnormal sugar metabolism (insulin resistance or diabetes), have blood pressure that is too high or have blood fats that are outside of acceptable ranges. This information will be measured and compared with the individuals’ clinical report of their physician’s or other health care professionals (nurses or therapists) advice of having these risks. As these risks may change with time after SCI, the Investigators are also interested in seeing whether this information changes after one and two years of living with a SCI.

 

Criteria

SCI men and women. 18 – 70 years old; Motor complete or incomplete, C5-L1, traumatic spinal injury; within 2 months of discharge from initial rehabilitation post-injury;

 

Duration

Approximately 24 months total, including a screening visit to assess risk for heart, blood vessel disease and blood sugar metabolism for the individual with SCI. Testing periods at time of enrollment, 12 months and 24 months after.

 

Enrollment Open Until

September 2020

 

Principal Investigator/Contact

Dr. Mark S. Nash / Dr. Luisa Betancourt