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Ian D. Hentall, Ph.D.

Research Associate Professor, Department of Neurological Surgery

Research Interests

Brainstem Influences on Neurotrauma and Related Conditions

Ian D. Hentall, Ph.D.
Ian D. Hentall, Ph.D.

We are interested in improving recovery from chronic neurodegenerative conditions by electrical deep brain stimulation (DBS). Our team works at present on spinal cord injury (SCI), traumatic brain injury (TBI) and multiple sclerosis (MS) in rats and mice. Also, we are currently studying DBS in a human clinical trial for SCI. The general idea behind our approach is that certain small brainstem regions (raphe nuclei) control and enhance repair, normally by relaying restorative feedback after injury. Part of our effort is on designing unique wireless implants that can give several weeks or more of DBS to rodents. With these implants, we have improved motor, sensory and autonomic recovery from SCI; motor and cognitive recovery from TBI; disease course in a mouse MS model (EAE), in collaboration with Dr. Roberta Brambilla of the Miami Project. We have found corresponding recovery of tissue in these models, and shown that the key signaling molecule cyclic AMP returns to normal in damaged brain or spinal cord upon raphe stimulation. In our future preclinical studies, we aim to expand the range of neurological deficits that can benefit from prolonged restorative DBS, while moving our ongoing findings towards clinical application.

TBI + SCI 2 Injury Model
TBI + SCI 2 Injury Model
CONTACT DETAILS

Ian D. Hentall, Ph.D.

  • The Miami Project to Cure Paralysis
    1095 NW 14th Terrace (R-48)
    Miami, FL 33136
  • IHentall@med.miami.edu
  • (305) 243-8184
  • (305) 243-3924
INFORMATION

PUBLICATIONS

 

PROFESSIONAL AFFILIATIONS/MEMBERSHIPS

Society for Neuroscience
National Neurotrauma Society

 

Name Title Phone Email
Melissa Carballosa-Gautam, Ph.D. Associate Scientist 305-243-8042 mcarballosa@med.miami.edu
Alberto Vitores, M.S. Clinical Research Coordinator 305-243-7806 avitores@med.miami.edu
Letitia Fisher Clinical Research Coordinator 305-243-7108 lfisher@med.miami.edu
Stephanie Sloley, B.S. Research Associate